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  • Sjogren’s syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth.

    The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus. In Sjogren’s syndrome, the mucous membranes and moisture-secreting glands of your eyes and mouth are usually affected first — resulting in decreased tears and saliva.

    Clinical features:

    2 main symptoms are :

    • Dry eyes
    • Dry mouth

    Some people with Sjogren’s syndrome also have one or more of the following:
    • Joint pain, swelling and stiffness
    • Swollen salivary glands — particularly the set located behind your jaw and in front of your ears
    • Skin rashes or dry skin
    • Vaginal dryness
    • Persistent dry cough
    • Prolonged fatigue
    Treatment for Sjogren’s syndrome depends on the parts of the body affected.


    Decrease eye inflammation. Prescription eyedrops such as cyclosporine may be recommended by your eye doctor if you have moderate to severe dry eyes.

    Increase production of saliva. Drugs such as pilocarpine and cevimeline can increase the production of saliva, and sometimes tears. Side effects can include sweating, abdominal pain, flushing and increased urination.

    Address specific complications. If you develop arthritis symptoms, you might benefit from nonsteroidal anti-inflammatory drugs (NSAIDs) or other arthritis medications. Yeast infections in the mouth should be treated with antifungal medications.

    Treat system wide symptoms. Hydroxychloroquine, a drug designed to treat malaria, is often helpful in treating Sjogren’s syndrome. Drugs that suppress the immune system, such as methotrexate also might be prescribed.